Moore was held out of practice on Wednesday with a quad injury, and although head coach Robert Saleh said the team was "hopeful" he would play this week, Moore was once again held out on Thursday.
Moore isn't the only key Jets player who could miss this week. Hughes said the same for right guard Laurent Duvernay-Tardif who hasn't practiced this week due to an ankle injury he suffered last week.
Running back Tevin Coleman and cornerback Michael Carter II have each been in concussion protocol this week and have not practiced yet. Friday's practice will be more telling, but it's not looking good for Moore and Duvernay-Tardif.
The NY Jets can't afford to be without Elijah Moore in Week 14
Moore's absence would likely be the most significant, especially following the loss of Corey Davis for the season after he was placed on the injured reserve earlier in the week.
The Jets are already down one of their top-two wide receivers — they can ill-afford to be down their other one.
If Moore were to be unable to play, the Jets would likely be forced to start Keelan Cole and Denzel Mims on the outside with Jeff Smith and perhaps Vyncint Smith, who was a practice squad protection this week, serving as their primary backups.
Hardly an ideal group of wide receivers for rookie quarterback Zach Wilson to work with. Wilson is coming off perhaps the best game of his brief NFL career, but losing Davis and Moore in the span of one week would certainly prove to be detrimental.
Duvernay-Tardif's absence would also be significant as the Jets would be forced to turn back to Greg Van Roten at right guard for the time being.
The Jets will hope to see one or both of these players return to practice on Friday. But as for now, their statuses for Sunday's game remain very much in doubt.